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KMID : 1134820160450030321
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Journal of the Korean Society of Food Science and Nutrition
2016 Volume.45 No. 3 p.321 ~ p.326
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Safety Study of Yeast Hydrolysate on a Postmenopausal Animal Model
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Jung Eun-Young
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Abstract
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The objective of this study was to obtain data on safety-in-use of yeast hydrolysate with a molecular weight of 10∼30 kDa as a dietary supplement by assessing its subacute oral toxicity in ovariectomized rats. Yeast hydrolysate did not produce mortality or significant changes in general behavior or gross appearance of internal organs of rats. There were no significant differences in organ weights between control and yeast hydrolysate groups. Hematological analysis and blood chemistry revealed no toxic effects of yeast hydrolysate. Neither gross abnormalities nor histopathological changes were observed. These results show that yeast hydrolysate possesses very low toxicity as indicated in a postmenopausal animal model.
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KEYWORD
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yeast hydrolysate, safety study, toxicity, postmenopause
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